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This also applies to profiling based on these provisions. This applies to profiling to the extent that it is related to such direct marketing. Some robot-assisted surgical systems have incorporated NIR fluorescence imaging to help visualize blood vessels and other anatomical features. Light with shorter wavelengths tends to scatter off of imperfections in objects that it strikes, but as wavelengths become longer, scattering is greatly reduced. Short-wave infrared can also penetrate deeper into tissue, although calculating exactly how far is a complicated process, the researchers say, because it depends on the size of the structure being viewed and the field of view of the microscope.

In the new study, the researchers were able to see several hundred micrometers into tissue using a regular fluorescence microscope. Normally, this depth can be reached only with two-photon microscopy, a much more complicated and expensive type of imaging. In their study, the researchers further explored ICG and showed that it gives a stronger signal than other SWIR dyes now in development. Previous studies of ICG had focused on its emission around nanometers, where it fluoresces the brightest, so no one had observed that the dye also produced a strong signal at longer wavelengths. The researchers also found that ICG is bright enough that it can produce images quickly, which is important for capturing motion.

The research team is now further investigating why ICG works so well for shortwave-infrared imaging, and is trying to identify the optimal wavelength for its use, which they hope will help them determine the best applications for this kind of imaging. They are also working with other labs to develop dyes that are similar to ICG and might work even better. To do shortwave-infrared imaging, research labs and hospitals would need to switch from the silicon cameras now used for NIR imaging to an indium gallium arsenide InGaAs camera. Until recently, these cameras have been prohibitively expensive, but the prices have been coming down in the past several years.


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